The U.S. artificial intelligence sector is experiencing another explosive year as 2025 matches — and in key areas surpasses — last year’s record-breaking momentum. In 2024, TechCrunch tracked 49 AI startups that secured funding rounds of $100 million or more. This year has already equaled that figure, with a noticeable rise in companies raising multiple nine-figure rounds.

From billion-dollar mega-rounds to massive seed investments, AI startups across infrastructure, healthcare, research, and enterprise solutions continue to attract aggressive backing from top venture firms and strategic investors.

Below is a month-by-month breakdown of U.S. AI startups that have raised at least $100 million in 2025:
November
Anysphere, creator of coding platform Cursor, raised $2.3 billion, valuing the company at $29.3 billion (second round this year).
Parallel, developing web infrastructure for AI agents, secured a $100 million Series A co-led by Index Ventures and Kleiner Perkins.
Hippocratic AI, focused on healthcare AI agents, raised $126 million Series C, valuing it at $3.5 billion (second round of 2025).

October
– Fireworks AI closed a $250 million Series C at a $4 billion valuation.
– Uniphore raised $260 million Series F, valuing the enterprise AI firm at $2.5 billion.
– Sesame, a voice AI startup, secured $250 million Series B co-led by Sequoia and Spark Capital.
– OpenEvidence raised $200 million Series C at a $6 billion valuation.
– Lila Sciences secured $350 million Series A for its science superintelligence platform.
– Reflection AI raised a massive $2 billion Series B, valuing the DeepSeek competitor at $8 billion.
– EvenUp, an AI legal platform, announced a $150 million Series E at over $2 billion valuation.

September
– Periodic Labs raised a $300 million seed round for its AI scientist platform.
– Cerebras Systems secured $1.1 billion Series G, valuing the firm at $8.1 billion.
– Modular raised $250 million led by the U.S. Innovative Technology Fund.
– Distyl AI closed a $175 million Series B at a $1.8 billion valuation.
– Upscale AI raised $100 million seed round for AI infrastructure development.
– Groq secured $750 million Series E, valuing the company at $6.9 billion.
– Invisible Technologies raised $100 million, reaching a $2 billion valuation.
– Cognition AI, maker of Devin, secured $400 million Series C at $10.2 billion valuation.
– Baseten raised $150 million Series D at $2.1 billion valuation.
– Sierra, built by Bret Taylor, secured $350 million, valuing it at over $10 billion.
– You.com closed $100 million Series C at a $1.5 billion valuation.
-Anthropic raised a monumental $13 billion Series F, valued at $183 billion.

August
– EliseAI raised $250 million Series E at $2.2 billion valuation.
– Decart, an AI research lab, secured $100 million at $3.1 billion valuation.

July
-Fal, a generative media platform, raised $125 million Series C at $1.5 billion valuation.
– Ambience Healthcare closed $243 million Series C.
– Reka AI secured $110 million Series B at a $1 billion valuation.
– Thinking Machines Lab raised $2 billion seed round, valuing it at $12 billion.
– OpenEvidence raised an additional $210 million (second round in 2025).
– Harmonic, building a mathematical reasoning engine, raised $100 million Series B.

June
– Abridge raised $300 million Series E at $5.3 billion valuation.
– Harvey closed a second $300 million round of the year, now valued at $5 billion.
– Tennr raised $101 million Series C.
– Glean raised $150 million Series F, valuing it at $7.25 billion.
– Anysphere raised $900 million Series C, nearing a $10 billion valuation.

May
– Snorkel AI secured $100 million Series D at $1.3 billion valuation.
– LMArena raised $100 million seed round at $600 million valuation.
– TensorWave raised $100 million Series A.

April
– SandboxAQ secured $450 million Series E at $5.7 billion valuation.
– Runway, an AI model creator for media, raised $308 million Series D at $3 billion valuation.

March
– OpenAI raised a historic $40 billion round, valuing the company at $300 billion.
– Nexthop AI raised $110 million Series A.
– Insilico Medicine closed $110 million Series E at $1 billion valuation.
– Celestial AI raised $250 million Series C, valued at $2.5 billion.
– Lila Sciences raised an additional $200 million seed round.
– Reflection.AI raised $130 million Series A.
– Turing secured $111 million Series E at a $2.2 billion valuation.
– Shield AI raised $240 million Series F at $5.3 billion valuation.
– Anthropic secured $3.5 billion Series E, valued at $61.5 billion.

February
Together AI raised $305 million Series B at $3.3 billion valuation.
Lambda raised $480 million Series D, valued at $2.5 billion.
Abridge raised $250 million Series D, valuing it at $2.75 billion.
Eudia secured $105 million Series A.
EnCharge AI raised $100 million Series B.
Harvey raised $300 million Series D, valued at $3 billion.

January
ElevenLabs secured $180 million Series C, valued above $3 billion.
Hippocratic AI raised $141 million Series B, valuing it at $1.6 billion.
With a surge of mega-rounds, new unicorns, and unprecedented investor appetite, 2025 is shaping up to be one of the most consequential years in U.S. AI funding history — one that may determine the next decade of global technological leadership.

Source: Techcrunch